International Society for Optical Engineering (SPIE): 2000
Slide 1
National Cancer Institute
Biomedical Imaging Program
Cancer Research: Because Lives Depend on It
Slide 2
New NCI Initiatives for CAD
Laurence P. Clarke PhD.
Barbara Y. Croft PhD.
Edward Staab MD.
Daniel Sullivan MD.
Slide 3
Image of CIP Organizational Chart
NCI Division of Cancer Treatment and Diagnosis (DCTD)
Cancer Diagnosis Program (CDP)
Biomedical Imaging Program (BIP)
- Diagnostic Imaging Branch
- Molecular Imaging Branch
- Image-guided Therapy Branch
- Imaging Technology Development Branch
Developmental Therapeutics Program (DTP)
Cancer Therapy Evaluation Program (CTEP)
Radiation Research Program (RRP)
Slide 4
NIH Funding for Imaging
Graph of Millions of Dollars vs years (FY 96, FY97, FY98, FY99) with 3 colors for BIP, NIH-Radiology and NIH Imaging funding levels
BIP varies from $50 million to about $80 million across the 4 years
NIH-Radiology varies from about $100 million to $120 million for 3 years
NIH Imaging varies from $325 million to $340 million for FY97 and FY98
Slide 5
BIP Grant Funding
Graph breaks out the BIP funding shown on the previous slide
Slide 6
Branch: Imaging Technology
- Promoting new areas for imaging technology development.
- Development of new funding initiatives for academia and industry, including SBIR/STTR’s.
- Development of research resources and centers of excellence.
- Promoting Inter-agency programs.
Slide 7
NIH Initiatives: Image Data Bases
- NLM/NSF Visible Human Project (1989-): CT/MRI images of to allow evaluation of image registration and segmentation (normal subjects/cadavers).
- NIH/NSF: Human Brain Project (1993-). Common tools to facilitate research on neuroinformatics (CT/PET/MRI).
- NCI Database (2000-2005): Focused on evaluation of diagnostic software for specific cancer applications and impact of image pre- processing( image registration).
Slide 8
Rationale: Image Database
- CAD methods: Rapidly being developed for more efficient analysis of screening studies (breast, lung and colon).
- Clinical Model: Spiral CT for lung cancer screening for high risk patients: Opportunity: access to clinical trials.
- Physical Model: Excellent for evaluating 3D CAD, image registration and temporal analysis of serial CT images, multi-modality image registration, image reconstruction.
Slide 9
Objectives: Image Database Resource
- Develop consensus for generation of retrospective image databases, histology confirmation and spatial ground truth, metrics and statistical methods for software evaluation.
- Provide an objective means to compare CAD, image processing, change analysis, and image reconstruction software methods.
- Stimulate development and early identification of promising software methods and reduction of research risk for academia and industry research sites.
- Enhance inter-disciplinary research collaboration by academia, federal laboratories and industry.
Slide 10
Subtle and Very Subtle Nodules Imaged on CT scan
Slide shows an x-ray computed tomography transaxial slice of the chest with 2 lung nodules marked.
Slide 11
CU0138-1
The slide, furnished by A. Reeves, Cornell University, 1999, shows an x-ray computed tomography transaxial slice of the chest with a nodule outlined and 8 successive slices above and below the one pictured. The image was acquired on June 17, 1996, with X and Y resolution of 0.68 mm and a slice thickness of 1 mm.
Slide 12
CU0138-1 3D Views
The slide, furnished by A. Reeves, Cornell University, 1999, shows a 3-dimensional rendering of the nodule shown on the previous slide. The nodule is broader in 1 dimension than in the other 2 and seems to be bumpy in texture.
Slide 13
U01: Cooperative Agreement
- Support 5 academic sites with fundable scores, selected by NCI, with ongoing lung cancer screening programs, to form a Lung Image Data Base Consortium (LIDC).
- LIDC: Minimum of 3 sites and two X-ray CT systems.
- U01 "Assistance mechanism" as opposed to a "contract".
- Steering committee: PI and Co-PI’s and NCI Program staff; responsible for forming consensus on research tasks.
- Concept Support: $7M for 5 years for 5 sites.
Slide 14
Future Plans: Technology Development
- Proposed PA: R21/R33 phased innovation for imaging technology development.
- RFP for ultrasound research interface
- RFA for spiral CT image database
- Proposed additional Centers with technology development component
Slide 15
NCI BIP WebPage
- URL = www.nci.nih.gov/dip/
- Email Newsletter : js95x@nih.gov
- lclarke@mail.nih.gov
- croftb@dtpepn.nci.nih.gov
Reports & Publications
Specialized Initiatives
- Phase 2 N01 Program
- Network for Translational Research
- Small Animal Imaging Resource Program (SAIRP)
- Current SAIRP Institutions and Principal Investigators
- University of Michigan
- M D Anderson Cancer Center
- University of Pennsylvania
- Memorial Sloan-Kettering Cancer Center
- Washington University
- Duke University
- Johns Hopkins University
- Massachusetts General Hospital
- Vanderbilt University
- University of California, Los Angeles
- Case Western Reserve University
- University of California at Davis
- University of Texas Southwestern
- ICMIC Institutions
- DCIDE