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Last Updated: 10/28/16

International Society for Optical Engineering (SPIE): 2000

Slide 1

National Cancer Institute
Biomedical Imaging Program
Cancer Research: Because Lives Depend on It

Slide 2

New NCI Initiatives for CAD

Laurence P. Clarke PhD.
Barbara Y. Croft PhD.
Edward Staab MD.
Daniel Sullivan MD.

Slide 3

Image of CIP Organizational Chart

NCI Division of Cancer Treatment and Diagnosis (DCTD)
Cancer Diagnosis Program (CDP)
Biomedical Imaging Program (BIP)

  • Diagnostic Imaging Branch
  • Molecular Imaging Branch
  • Image-guided Therapy Branch
  • Imaging Technology Development Branch

Developmental Therapeutics Program (DTP)
Cancer Therapy Evaluation Program (CTEP)
Radiation Research Program (RRP)

Slide 4

NIH Funding for Imaging

Graph of Millions of Dollars vs years (FY 96, FY97, FY98, FY99) with 3 colors for BIP, NIH-Radiology and NIH Imaging funding levels
BIP varies from $50 million to about $80 million across the 4 years
NIH-Radiology varies from about $100 million to $120 million for 3 years
NIH Imaging varies from $325 million to $340 million for FY97 and FY98

Slide 5

BIP Grant Funding

Graph breaks out the BIP funding shown on the previous slide

Slide 6

Branch: Imaging Technology

  • Promoting new areas for imaging technology development.
  • Development of new funding initiatives for academia and industry, including SBIR/STTR’s.
  • Development of research resources and centers of excellence.
  • Promoting Inter-agency programs.

Slide 7

NIH Initiatives: Image Data Bases

  • NLM/NSF Visible Human Project (1989-): CT/MRI images of to allow evaluation of image registration and segmentation (normal subjects/cadavers).
  • NIH/NSF: Human Brain Project (1993-). Common tools to facilitate research on neuroinformatics (CT/PET/MRI).
  • NCI Database (2000-2005): Focused on evaluation of diagnostic software for specific cancer applications and impact of image pre- processing( image registration).

Slide 8

Rationale: Image Database

  • CAD methods: Rapidly being developed for more efficient analysis of screening studies (breast, lung and colon).
  • Clinical Model: Spiral CT for lung cancer screening for high risk patients: Opportunity: access to clinical trials.
  • Physical Model: Excellent for evaluating 3D CAD, image registration and temporal analysis of serial CT images, multi-modality image registration, image reconstruction.

Slide 9

Objectives: Image Database Resource

  • Develop consensus for generation of retrospective image databases, histology confirmation and spatial ground truth, metrics and statistical methods for software evaluation.
  • Provide an objective means to compare CAD, image processing, change analysis, and image reconstruction software methods.
  • Stimulate development and early identification of promising software methods and reduction of research risk for academia and industry research sites.
  • Enhance inter-disciplinary research collaboration by academia, federal laboratories and industry.

Slide 10

Subtle and Very Subtle Nodules Imaged on CT scan

Slide shows an x-ray computed tomography transaxial slice of the chest with 2 lung nodules marked.

Slide 11


The slide, furnished by A. Reeves, Cornell University, 1999, shows an x-ray computed tomography transaxial slice of the chest with a nodule outlined and 8 successive slices above and below the one pictured. The image was acquired on June 17, 1996, with X and Y resolution of 0.68 mm and a slice thickness of 1 mm.

Slide 12

CU0138-1 3D Views

The slide, furnished by A. Reeves, Cornell University, 1999, shows a 3-dimensional rendering of the nodule shown on the previous slide. The nodule is broader in 1 dimension than in the other 2 and seems to be bumpy in texture.

Slide 13

U01: Cooperative Agreement

  • Support 5 academic sites with fundable scores, selected by NCI, with ongoing lung cancer screening programs, to form a Lung Image Data Base Consortium (LIDC).
  • LIDC: Minimum of 3 sites and two X-ray CT systems.
  • U01 "Assistance mechanism" as opposed to a "contract".
  • Steering committee: PI and Co-PI’s and NCI Program staff; responsible for forming consensus on research tasks.
  • Concept Support: $7M for 5 years for 5 sites.

Slide 14

Future Plans: Technology Development

  • Proposed PA: R21/R33 phased innovation for imaging technology development.
  • RFP for ultrasound research interface
  • RFA for spiral CT image database
  • Proposed additional Centers with technology development component

Slide 15