Radiological Society of America (RSNA): 1999
Cover Page
National Cancer Institute
Biomedical Imaging Program
Cancer Research: Because Lives Depend on It
National Institutes of Health
National Cancer Institute
Biomedical Imaging Program
Biomedical Imaging Program: Update
Money
Organizational comments
Current Programs
Future Plans
Concluding comments
NIH Funding for Imaging
Graph of Millions of Dollars vs years (FY 96, FY97, FY98, FY99) with 3 colors for BIP, NIH-Radiology and NIH Imaging funding levels
BIP varies from $50 million to about $80 million across the 4 years
NIH-Radiology varies from about $100 million to $120 million for 3 years
NIH Imaging varies from $325 million to $340 million for FY97 and FY98
CIP Grant Funding
Graph breaks out the BIP funding shown on the previous slide
NIH Funding For Imaging
Image of CIP Organizational Chart
NCI Division of Cancer Treatment and Diagnosis (DCTD) Cancer Diagnosis Program (CDP)
Biomedical Imaging Program (BIP)
- Diagnostic Imaging Branch
- Molecular Imaging Branch
- Image-guided Therapy Branch
- Imaging Technology Development Branch
Developmental Therapeutics Program (DTP)
Cancer Therapy Evaluation Program (CTEP)
Radiation Research Program (RRP)
Organization
10 FTE’s D Sullivan, L Clarke, J Hoffman, A Menkens, B Croft, M Torres, J Smith, L Cooley, S Bowles, L Banh
3 Part-time E Staab, J Tatum, C Langlotz
Further expansion is space limited
Positions available
(of importance to imaging)
NHLBI Program Director
NCI Scientific Review Administrator
Molecular Imaging Publication
Image of top of page of Editoral entitled "Molecular Imaging: Exploring the Next Frontier" by Ralph Weissleder, M.D., Ph.D., which appeared in Radiology 1999;212:609-614.
Recent Programs
A table of recent programs
Programs | Awards | Amount |
---|---|---|
RFA: CA-97-020: Cooperative Trials in Diagnostic Imaging (ACRIN) | 2 U01 | $3.0 M year 1 $22 M Total |
RFA: CA-98-024: Development and Application of Imaging in Therapeutic Studies | 9 R01’s | $2.8 M year 1 $11.6 M Total |
CA-98-023: Small Animal Imaging Resource Programs (SAIRPs) | 5 R24s | $5.3 M year 1 $15.3 M Total |
Current Programs(1)
A table of Current Programs (first slide)
Program Awards | Awards | Amount |
---|---|---|
RFA: CA-99-002: Planning Grants - Molecular and Cellular Imaging Centers (Pre-ICMICs) | 6-8 P20/s | $2.4 M year 1 $7.2 M total |
RFA: CA-909-004: Molecular and Cellular Imaging Centers (ICMIC’s) | 2 P50s per year | $4.0 M year 1 $48M Total |
RFA: CA-99-015: Diagnostic Imaging and Guided Therapy in Prostate Cancer (Phased Innovation Award) | 6-8 R21/R33 | $1.6 M year 1 $19.6 M Total |
PAR-99_049: Diagnostic Imaging and Guided Therapy in Prostate Cancer: SBIR/STTR Initiative | R43/R44 | Payline |
Current Programs(2)
A table of Current Programs (second slide)
Programs | Awards | Amount |
---|---|---|
NCI: CIP/OWH: PA: 99-082 / 083: Development and Testing of Digital Mammography Displays and Workstations (R0I/ SBIR/STTR) | R01s, SBIR/STTR | Payline |
NCI/CIP: PA: 98-008: Exploratory/Developmental Grants for Diagnostic Cancer Imaging (R21s) | R21s | $5.7 M year 1 |
PAR-98-101: Innovative Technologies for the Molecular Analysis of Cancer: Phased Innovation Award | R21/R33 SBIR/STTR (PAR-98-100) | Payline |
PAR-98-102: Applications Of Innovative Technologies For The Molecular Analysis Of Cancer | R21/R33 SBIR/STTR (PAR-98-103) | Payline |
PAR-98-010: Bioengineering Research Partnership Programs | R01s | Payline |
PAR-08-009: Bioengineering Research Grants (BRG) | R01s | Payline |
BAA No. N01-CM087065-82 Novel Technologies for Noninvasive Detection, Diagnosis, and Treatment of Cancer | Contracts | $4 M year 1 $16 M total |
Collaborative Programs
A table of collaborative programs.
Programs | Awards | Amount |
---|---|---|
PA-98-092: Shared Resources for Scientists Outside NCI Cancer Centers | R01 or P01 | Payline |
NLM 99-103: Visible Human Project Image Processing Tools (NLM) | Contracts | |
RFA: AI-99-004: New Imaging Technologies for Autoimmune Diseases | R01s | $3.5 M year 1 $17.5 M total |
RFA: CA-99-013: Cancer Intervention and Surveillance Modeling Network (CISNET) | U01s | $1.5 M year 1 |
$6.0 M total |
CTEP Collaborative Programs
A table of CTEP collaborative programs (Cancer Trials E Program)
Program | Awards |
---|---|
CTEP Protocol Review | Contracts, U01s |
CA-98-007: Pediatric Brain Tumor Clinical Trials Consortium | U01, imaging required |
RFAs for new Centers | U54s, imaging required |
RFP for Phase I & II clinical trials | Contracts, imaging required |
CIP Standards Activities
DICOM / Working Group on Clinical Trials Data
RSNA - IHE / RSNA - image archive collaborations
Structured reporting collaborations: DICOM, SNOMED, ACR, RSNA
Image database standards: RFA
NCI - Imaging Industry Relations Forum
Clear description of HCFA decision rules
Policy for conditional coverage of emerging imaging technologies
Re-evaluation of FDA policies, esp. re: tracers or procedures of low risk
Assure full range of NCI support mechanisms for imaging science.
NCI Training Activities
Education and Career Grants
R25 Cancer Education and Career Development Program
R25 Cancer Education and Career Development Program
Multidisciplinary
Institutional award
Salary support for PI and core faculty
Trainee salary up to $75,000
Research support up to $20,000 per trainee
5 yr. grant, renewable
8% indirect
K07 / K08 / K23
K 07 Epidemiology
(limited use by radiology)
K 08 Clinician: Bench science
(limited use by radiology)
K23 Clinician: Patient-oriented (hands-on; obtain consent form)
(no imaging applications yet)
Salary $75,000/ Research $30,000
Training Grants
Imaging
From 1/97 to 10/99 (6 NCI deadlines)
- 54.2% of T32 applications submitted to NCI were funded
- 6.5% of applications submitted were imaging-related
- 57.1% of imaging-related T32s were funded
T32 Training Grants - Imaging
Years | Principal Investigator | Title |
---|---|---|
24 | Kuhl, David | Cancer Research Training in Nuclear Medicine |
17 | Wagner, Henry | Res. Training in the Use of Tracer Principles in Oncology |
14 | Brady, Thomas | Nuclear Magnetic Resonance |
10 | Zerhouni, Elias | Research Training in Oncology Imaging |
7 | Glazer, Gary | Advanced Techniques for Cancer Imaging |
5 | Clouse, Melvin | Deaconess Research Training in Cancer Radiology |
4 | Baum, Stanley | Training in Innovative Cancer Imaging Technologies |
3 | Hawkins, Randall | Research Training in Diagnostic Oncology |
2 | Wehrli, Felix | Training in Quantitative Magnetic Resonance Imaging |
23 | Hoffman, Edward | Research Training in Biomedical Physics |
23 | Bedford, Joel | Radiological Sciences Basic to Cancer Research |
21 | DeLuca, Paul | U. W. Radiological Sciences Training Program |
18 | Alpert, Nathaniel | Postgraduate Program in Radiological Science |
10 | Doi, Kunio | Research Training in Medical Physics |
Research Training Grant Information
Call Brian Kimes
301 496 8537
email:
bk34t@nih.gov
Future Plans - Devices
Proposed PA: R21/R33 for imaging technology development
RFP for ultrasound research interface
RFA for spiral CT image database
Proposed program to support production of beta units for clinical trials
Proposed additional Centers with technology development component
Future Plans - Pharmaceuticals
(Imaging agents)
Pharmaceutical categories of interest:
- Non-PET tracers
- PET tracers
- Bulk agents (pharmacologic effect)
- Radiolabeled therapeutic agents (non-sealed-source agents)
Future Plans - Pharmaceuticals
(Imaging agents)
Proposed program to support development of novel imaging probes.
Proposed program to support R & D necessary for IND, and provide supply needed for clinical trials.
Concluding Comments
Molecular imaging is future priority
CIP funding increased 40 %
More applications lead to more funding
Patient accrual needs attention
Rewards for team science need attention
Think R25 for research training grants
Sources of NCI imaging information to public
Website: URL = www.nci.nih.gov/dip/
Email Newsletter
Reports & Publications
Specialized Initiatives
- Phase 2 N01 Program
- Network for Translational Research
- Small Animal Imaging Resource Program (SAIRP)
- Current SAIRP Institutions and Principal Investigators
- University of Michigan
- M D Anderson Cancer Center
- University of Pennsylvania
- Memorial Sloan-Kettering Cancer Center
- Washington University
- Duke University
- Johns Hopkins University
- Massachusetts General Hospital
- Vanderbilt University
- University of California, Los Angeles
- Case Western Reserve University
- University of California at Davis
- University of Texas Southwestern
- ICMIC Institutions
- DCIDE