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Research & Funding

Past CIP InitiativesRSS

This page lists past opportunities from CIP.

Requests for Application (RFA) are usually announced with special application dates; there is no possibility for applying after that date. Program Announcements (PA, PAR) may be open for a set period of time, such as 3 years or less; applications submitted in response to Program Announcements may be due on the standard dates (February 1, June1, and October 1) or may have special dates for receipt of applications. Please pay attention to these dates. Contact a CIP staff member if you have questions.

  • PAR-14-013: Early Phase Clinical Trials in Imaging and Image-Guided Interventions (R21) - Reissued

    • Release Date: March 05, 2014
    • Application Receipt Date: June 30, 2014; October 10, 2014; February 9, 2015, June 9, 2015; October 9, 2015; February 9, 2015; June 9, 2016; October 11, 2016; February 9, 2017, by 5:00 PM local time of applicant organization.
    • Expiration Date: February 10, 2017
    • Contacts: Imaging trials:
      Lori A. Henderson, Ph.D., NCI, Phone: 240-276-5930, (hendersonlori@mail.gov)
      Frank I. Lin, M.D., NCI, Phone: 240-276-5932, (frank.lin2@nih.gov)
      Image-Guided Intervention [IGI] trials:
      Keyvan Farahani, Ph.D., NCI, Phone: 240-276-5921, (farahank@mail.nih.gov)
      Radiation Therapy related trials:
      Bhadrasain Vikram, M.D., NCI, Phone: 240-276-5690, (vikramb@mail.nih.gov)

    This Funding Opportunity Announcement (FOA) is intended to support clinical trials conducting preliminary evaluation of the safety and efficacy of imaging agents, as well as an assessment of imaging systems, image processing, image-guided therapy, contrast kinetic modeling, 3-D reconstruction and other quantitative tools. As many such preliminary evaluations are early in development, this FOA will provide investigators with support for pilot (Phase I and II) cancer imaging clinical trials, including patient monitoring and laboratory studies. This FOA supports novel uses of known/standard clinical imaging agents and methods as well as the evaluation of new agents, systems, or methods. The imaging and image-guided intervention (IGI) investigations, if proven successful in these early clinical trials, can then be validated in larger studies through competitive R01 mechanisms, or through clinical trials in the Specialized Programs of Research Excellence (SPOREs), Cancer Centers and/or the NCI's National Clinical Trials Network.

  • PAR-11-216: Early Phase Clinical Trials in Imaging and Image-Guided Interventions (R21)

    • Release Date: May 24, 2011
    • Application Receipt Date: See below
    • Expiration Date: March 14, 2014
    • Contacts:

      Imaging trials:

      Lalitha K. Shankar, M.D., Ph.D., NCI, Phone: 240-276-6510, (shankarl@mail.nih.gov)
      Frank I. Lin, M.D., NCI, Phone: 240-276-5932, (frank.lin2@nih.gov)

      Image-Guided Intervention trials:

      Keyvan Farahani, Ph.D., NCI, Phone: 240-276-5921, (farahank@mail.nih.gov)

      Radiation Therapy trials:

      Bhadrasain Vikram, M.D., NCI, Phone: 240-276-5690, (vikramb@mail.nih.gov)

    • Application Receipt/Submission Date(s): July 27, 2011; November 10, 2011; March 13, 2012; July 11, 2012; November 13, 2012; March 13, 2013; July 11, 2013; November 13, 2013; March 13, 2014, by 5:00 PM local time of applicant organization.

    This Funding Opportunity Announcement (FOA) is intended to support clinical trials conducting preliminary evaluation of the safety and efficacy of imaging agents, as well as an assessment of imaging systems, image processing, image-guided therapy, contrast kinetic modeling, and 3-D reconstruction and other quantitative tools. As many such preliminary evaluations are early in development, this FOA will provide investigators with support for pilot (Phase I and II) cancer imaging clinical trials, including patient monitoring and laboratory studies. The imaging and Image-guided Intervention (IGI) investigations, if proven successful in these early clinical trials, can then be validated in larger studies through competitive R01 mechanisms, or through clinical trials in the Specialized Programs of Research Excellence (SPOREs), Cancer Center and/or Cooperative Groups.

    See full description in NIH Guide: PAR-11-216;

  • PAR-11-150: Quantitative Imaging for Evaluation of Responses to Cancer Therapies (U01)

    • Release Date: March 14, 2011
    • Application Receipt Date: Standard dates
    • Expiration Date: May 8, 2014
    • Contacts:

      Robert J. Nordstrom, Ph.D. (nordstrr@mail.nih.gov) at 240-276-5934

    The Cancer Imaging Program, (NCI), solicits applications to promote research on quantitative imaging of tumor response to cancer therapies in clinical trial settings, with the overall goal of facilitating clinical decision making. Proposed projects should include the appropriate development and adaptation/implementation of quantitative imaging methods, protocols and software solutions/tools (using existing commercial imaging platforms and instrumentation), and their application in current and planned Phase 1-2 clinical therapy trials. No support for the clinical trials, as such, will be provided under this initiative. The proposed projects must focus on imaging-derived quantitative measurements of responses to drugs and/or radiation therapy, and/or image-guided interventions. It is anticipated that these research goals will require multidisciplinary efforts. Therefore, this announcement solicits applications from multi-disciplinary teams to include oncologists as well as clinical and basic imaging scientists. The involvement of industrial partners in the development of the quantitative imaging methods is not required, but is strongly encouraged. Awardees form a Quantitative Imaging Network (QIN) to share ideas and approaches to validate and standardize imaging data and related imaging meta-data for quantitative measurements of responses to cancer therapies.

    See the CIP QIN website for a description of the program.

    • No set-aside

    See full description in NIH Guide: PAR-11-150

    Clarification of Scope and Requirements of PAR-11-150: NOT-CA-11-011

  • PA-10-080 and PA-10-079: Image-Guided Interventions (STTR [R41/R42] & SBIR [R43/R44])

    • Release Date: January 08, 2010
    • Application Receipt Date: Multiple dates, see announcements.
    • Expiration Date: January 8, 2013
    • Contacts:

      David Beylin, M.S., NCI, Phone: 301-496-0079, Email: beylind@mail.nih.gov
      Expires January 8, 2013

    These Funding Opportunity Announcements (FOA) support the development and clinical validation of systems for image-guided interventions (IGIs) for cancer. Specifically, the goals of this program are to provide support for: the development and optimization of fully integrated cancer imaging, monitoring, and therapy systems; the validation of integrated IGI systems through clinical evaluations; the development of multiple prototype integrated IGI systems as required for multisite clinical evaluations; and partnerships among small business, large business, and academic clinical centers, as well as small business joint ventures, in order to reach the research goals..

    See full description in NIH Guide: STTR (R41/R42) PA-10-080; SBIR (R43/44) PA-10-079

  • PA-09-253: Image-guided Drug Delivery in Cancer (R01)

    • Release Date: August 13, 2009
    • Application Receipt Date: Standard dates
    • Expiration Date: May 8, 2013
    • Contacts:

      Contact: Keyvan Farahani, Ph.D. (farahank@mail.nih.gov) at 240-276-5921

    The NCI encourages innovative translational research in the development of quantitative in vivo imaging characterization of image-guided drug delivery (IGDD) in cancer, including characterizations of the target, delivery validation, and therapy response. This initiative will support research in development of integrated imaging-based platforms for multifunctional and multiplexed drug delivery systems in cancer. Validation studies in non-human primates or large animal models and first in human studies directed towards translation of IGDD technology into the clinic will be considered appropriate for this initiative.

    • No set-aside

    See full description in NIH Guide: PA-09-253

  • PAR-09-157: In vivo Cellular and Molecular Imaging Centers (ICMICs) (P50)

    • Release Date: April 13, 2009
    • Application Receipt Date: October 28, 2009, October 28, 2010, October 28, 2011
    • Expiration Date: October 29, 2011
    • Contacts:

      Anne Menkens, Ph.D. (am187k@nih.gov) at 301-496-9531

    The Cancer Imaging Program, and the Division of Cancer Diagnosis and Treatment, at the National Cancer Institute (NCI), invite new or renewal (competing) applications for P50 Research Center Grants for In vivo Cellular and Molecular Imaging Centers (ICMICs). The program will fund the 5-year P50 ICMIC grants to support interdisciplinary scientific teams conducting cutting-edge cancer molecular imaging research. ICMIC funding is designed to: (1) support innovative cancer molecular imaging research projects; (2) support unique core facilities; (3) enable the awardees to initiate pilot research in new promising directions; and (4) provide interdisciplinary career development opportunities for investigators new to the field of molecular cancer imaging.

    • Letters of Intent Receipt Dates: September 28, 2009, September 28, 2010, September 28, 2011
    • No set-aside

    See full description in NIH Guide:PAR-09-157

  • PAR-08-225: Quantitative Imaging for Evaluation of Responses to Cancer Therapies (U01)

    • Release Date: August 03, 2008
    • Application Receipt Date: Standard dates
    • Expiration Date: May 8, 2011
    • Contacts:

      Robert J. Nordstrom,  Ph.D. (nordstrr@mail.nih.gov) at 301-594-9121

    The Cancer Imaging Program, (NCI), solicits applications to promote research on quantitative imaging of tumor response to cancer therapies in clinical trial settings, with the overall goal of facilitating clinical decision making. Proposed projects should include the appropriate development and adaptation/implementation of quantitative imaging methods, protocols and software solutions/tools (using existing commercial imaging platforms and instrumentation), and their application in current and planned Phase 1-2 clinical therapy trials. No support for the clinical trials, as such, will be provided under this initiative. The proposed projects must focus on imaging-derived quantitative measurements of responses to drugs and/or radiation therapy, and/or image-guided interventions. It is anticipated that these research goals will require multidisciplinary efforts. Therefore, this announcement solicits applications from multi-disciplinary teams to include oncologists as well as clinical and basic imaging scientists. The involvement of industrial partners in the development of the quantitative imaging methods is not required, but is strongly encouraged. Awardees will form a Quantitative Imaging Network (QIN) to share ideas and approaches to validate and standardize imaging data and related imaging meta-data for quantitative measurements of responses to cancer therapies.

    • No set-aside

    See full description in NIH Guide: PAR-08-225

  • PAR-08-147: Quick-Trials for Imaging and Image-Guided Interventions: Exploratory Grants (R21) (NCI)

    • Release Date: April 15, 2008
    • Expiration Date: April 12, 2011
    • Contacts:

      Barbara Galen, M.S.N., C.R.N.P., C.N.M.T., NCI, Phone: 301-594-5225, Email: bgalen@mail.nih.gov
      Lalitha Shankar, M.D., NCI, Phone: 301-496-9531, Email: shankarl@mail.nih.gov
      Keyvan Farahani, Ph.D., NCI, Phone: 301-451-2651, Email: farahank@mail.nih.gov

    The goal of this Funding Opportunity Announcement (FOA) is to support clinical trials conducting preliminary evaluation of the safety and efficacy of imaging agents, as well as an assessment of imaging systems, image processing, image-guided therapy, contrast kinetic modeling, and 3-D reconstruction and other quantitative tools. The rapid translation of promising discoveries in the fields of imaging probes, methodologies, technologies and image-guided therapies to clinical practice requires timely support. This FOA will provide investigators with support for either pilot (Phase I and II) cancer clinical trials, or patient monitoring and laboratory studies. The imaging and Image-guided Intervention (IGI) studies, if proven successful in these early clinical trials, can then be validated in larger studies through competitive R01 mechanisms, or through clinical trials in the Specialized Programs of Research Excellence (SPOREs), Cancer Centers and/or Cooperative Groups.

    Mechanism of support: This FOA will use the NIH Exploratory/Developmental (R21) grant mechanism

    See full description in NIH Guide:PAR-08-147

    For instructions on the inclusion of clinical protocols in the PAR-08-147 application, see NOT-CA-10-019

  • PAR-08-025: Quick-Trials for Novel Cancer Therapies and Prevention: Exploratory Grants (R21)

    • Release Date: November 19, 2007
    • Expiration Date: November 10, 2010
    • Contacts:

      Heng Xie, Ph.D.,, NCI, Phone: 301-496-8866, Email: xiehe@mail.nih.gov

    This Funding Opportunity Announcement (FOA) is intended to promote translational research in new agent/modality development with timely exploitation of new cancer-relevant therapeutic and/or preventive strategies that involve defined molecular targets. Applications are solicited for pilot clinical trials exploring individual anticancer agents/modalities and/or their combinations in the context of specific molecular targets. Applicants may propose Phase 0, Phase I, Phase II, and/or other pilot cancer clinical trials. In addition, patient monitoring and laboratory correlative studies related to clinical trials may be proposed. Applications that explore complementary and alternative approaches for cancer prevention and/or treatment are also encouraged. Clinical trials proposed may be oriented on AIDS-associated malignancies and cancer-related nutritional interventions. Applicants must include the clinical protocol within the Appendix to ensure proper accelerated peer review with the goal of issuing new awards within 6 months of receipt of the grant application.

    Mechanism of Support: This FOA will use the NIH Exploratory/Developmental (R21) grant mechanism

    See full description in NIH Guide:PAR-08-025

  • RFA-CA-08-002: Network for Translational Research (NTR): Optical Imaging in Multimodal Platforms (U54)

    This Funding Opportunity Announcement (FOA) issued by the National Cancer Institute (NCI) is an open competition initiative, designed to continue the efforts of the NCI to develop and translate cancer-relevant optical imaging technologies as a part of an overall imaging program for early cancer detection, diagnosis, therapeutic response, drug development, and image-guided therapy. This FOA stems from the previous initiative on optical imaging technology. However, the program structure and goals of the current FOA differ from those of the original program. Accordingly, all responses to this FOA will be considered new applications, with the main objective being to accelerate the translational research of in vivo multimodal imaging and/or spectroscopic platforms from the laboratory and pre-clinical level to the clinical level. Applications are sought from multi-disciplinary, multi-institutional research teams. After the awards, successful teams will become Centers that will be organized into an interactive network. The network will be called the "Network for Translational Research: Optical Imaging" (NTR). The purpose of NTR is to develop, optimize, and validate imaging technology platforms and methods so that they can enter single or multi-site clinical trials and eventually be incorporated into clinical practice. Applicants responding to this FOA must identify a specific cancer-relevant clinical goal and propose to develop and validate at least one multimodal imaging platform, as defined in this FOA, to address this clinical goal.

    • Letters of Intent Receipt Date: December 24, 2007
    • Set-aside funds: $4.8M per year, $24M over 5 years; approximately 4 awards

    See full description in NIH Guide: RFA-CA-08-002