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Research & Funding

Current CIP InitiativesRSS

This page lists current opportunities from CIP.

For information about the funding process, go to Mechanisms or Guidelines.

The NCI's Division of Extramural Activities provides information about newly approved concepts, which may become RFAs and PAs. Check the Concepts Cleared at the NCI Board of Scientific Advisors Meeting web site for the earliest possible information about future initiatives.

  • PAR-14-166: Early Phase Clinical Trials in Imaging and Image-Guided Interventions (R01)

    • Release Date: April 01, 2014
    • Application Receipt Date: June 30, 2014; Oct 10, 2014; Feb 9, 2015; June 9, 2015; Oct 9, 2015; Feb 9, 2016; June 9, 2016; Oct 11, 2016; Feb 9, 2017
    • Expiration Date: Feb 10, 2017
    • Contacts:

      Imaging trials:
      Lori A. Henderson, Ph.D., NCI, Phone: 240-276-5930, (hendersonlori@mail.gov)
      Frank I. Lin, M.D., NCI, Phone: 240-276-5932, (frank.lin2@nih.gov)
      Image-Guided Intervention [IGI] trials:
      Keyvan Farahani, Ph.D., NCI, Phone: 240-276-5921, (farahank@mail.nih.gov)
      Radiation Therapy related trials:
      Bhadrasain Vikram, M.D., NCI, Phone: 240-276-5690, (vikramb@mail.nih.gov)

    EXPLANATORY NOTE:  This is a new R01 grant-funded program announcement that supports Phase I/II clinical trials in imaging and IGI.  Funds up to $500,000 in direct costs for a total project period of 2 or 3 years will be provided with a limit of $250,000 in direct costs in any single year.  The previous R21 grant-funded program announcement referred to as PAR-14-013 has been terminated.    Please see the FOA for explicit details including sections:  (1) SF-424 (R&R) - Other Project Information and, (2) Application Review Information which highlights clinical trial protocol and background information requirements respectively.

  • PAR-14-116: Quantitative Imaging for Evaluation of Response to Cancer Therapies (U01)

    • Release Date: March 18, 2014
    • Application Receipt Date: Standard dates apply, see http://grants.nih.gov/grants/funding/submissionschedule.htm
    • Expiration Date: Feb 6, 2017
    • Contacts:

      Robert J. Nordstrom, Ph.D., Phone: 240-276-5934, Email: nordstrr@mail.nih.gov
      James A. Deye, Ph.D., Phone: 240-276-5690, Email: deyej@mail.nih.gov

    This Funding Opportunity Announcement (FOA) invites research project - cooperative agreement (U01) applications which are expected to enhance the value of quantitative imaging (QI) in clinical trials for prediction and/or measurement of response to cancer therapies.  One avenue for this enhancement is to emphasize the development, optimization and validation of state-of-the-art QI methods and software tools for potential implementation in single site phase 1 or 2 clinical trials. The second avenue to enhance QI methods is to address the challenges of integrating existing and or new QI methods as required for multicenter phase 3 clinical trials. This may involve evaluation of a range of multimodal imaging approaches, harmonization of image data collection, analysis, display and clinical workflow methods across imaging platforms, or testing their performance across different cancer sites.

    Because this validation process is complex, a single research program cannot be expected to complete every detail from initial tool development to final integration into clinical trials. Therefore, it is anticipated that these research goals will require multidisciplinary efforts. Although the involvement of industrial partners in the development of the QI methods is not required, it is strongly encouraged. Awardees will also join the Quantitative Imaging Network (QIN) to share ideas and approaches in order to validate and standardize imaging data and related imaging metadata for quantitative measurements of prediction and/or response to cancer therapies.

    See the CIP QIN Website for a description of the program.

  • PAR-13-185: Image-guided Drug Delivery in Cancer (R01)

    • Release Date: May 14, 2013
    • Application Receipt Date: June 19, 2013; November 19, 2013; June 19, 2014; November 19, 2014; June 19, 2015; November 19, 2015
    • Expiration Date: November 20, 2015
    • Contacts:

      Contact: Keyvan Farahani, Ph.D. (farahank@mail.nih.gov) at 240-276-5921

      Please see the FOA for a complete list of contacts.

    This Funding Opportunity Announcement (FOA) will support innovative research projects that are focused on image-guided drug delivery (IGDD), including real-time image guidance, monitoring, quantitative in vivo characterizations and validation of delivery and response. It will support research in development of integrated imaging-based platforms for multifunctional and multiplexed drug delivery systems in cancer and other diseases, quantitative imaging assays of drug delivery, and early intervention.

  • PAR-13-169: Academic-Industrial Partnerships for Translation of in vivo Imaging Systems for Cancer Investigations (R01)

    • Release Date: May 14, 2013
    • Application Receipt Date: Standard dates apply: see http://grants.nih.gov/grants/funding/submissionschedule.htm
    • Expiration Date: May 8, 2016
    • Contacts:

      Houston Baker, Ph.D.; Phone: 240-276-5908; Email: bakerhou@mail.nih.gov

      Please see the FOA for a complete list of contacts.

    This Funding Opportunity Announcement (FOA) encourages applications from research partnerships formed by academic and industrial investigators to accelerate the translation of either preclinical or clinical in vivo imaging systems and/or methods that are designed to solve a targeted cancer problem. The proposed imaging system/methods may include single or multi-modality in vivo imaging and spectroscopy systems, image-guided and drug delivery systems, image analysis, and related research resources. This FOA may also include, as a secondary goal, support for other laboratory imaging or reference methods as required to validate the performance of the proposed in vivo imaging system and/or methods. Funding may be requested to enhance, adapt, optimize, validate, and otherwise translate the following examples, among others: (a) current commercially supported imaging systems/methods, (b) next-generation imaging systems/methods, (c) quality assurance and quality control methods, (d) validation and correlation studies, (e) quantitative imaging methods, and (f) related research resources. Because appropriate applications must be translational in scope, this FOA defines innovation as a coherent translational plan to deliver emerging or new capabilities for preclinical or clinical use that are not yet broadly employed in preclinical or clinical settings. The partnerships on each application should establish an inter-disciplinary, multi-institutional research team to work in strategic alliance to implement a coherent strategy to develop and translate their proposed imaging system/methods to solve a targeted cancer problem. This FOA will support clinical trials that emphasize optimization and validation of the performance of imaging systems, including devices, agents and/or methods. This FOA will not support commercial production, or basic research projects that do not emphasize translational development and optimization of the methods for a targeted cancer problem.

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