• Release/Posted Date: July 27, 2007
• Letters of Intent Receipt Date(s): August 27, 2007, August 16, 2008, August 17, 2009
• Application Receipt Dates: September 28, 2007, September 18, 2008, September 18, 2009
• Contact: Suresh Mohla, Ph.D.; Phone: 301-435-1878; E-mail: mohlas@mail.nih.gov
• Expiration Date: September 19, 2009

This Funding Opportunity Announcement issued by the National Heart, Lung, and Blood Institute (NHLBI), in conjunction with other Institutes, solicits Research Project Grant (R01) applications from qualified researchers to investigate the biology of the lymphatic system and potential new therapeutic implications. The purpose of this program announcement is to stimulate research on the biology of the lymphatic system at all biologic levels: molecular, cellular, tissue, organ, and whole body levels. Further, it includes research on innovations for identifying and intervening in lymphatic diseases across all age groups and disease states. Examples of potential areas of research pertinent to NCI participation in PAR-07-420 are listed in the announcements. Among the examples are a) Molecular characterization and comparison of normal and tumor lymphatic endothelia and their component cells, including identifications of molecular markers, secreted factors, and/or receptors;b) Determination of the functional status of tumor lymphatic vessels, e.g. the uptake and transport of fluid and macromolecules; c)Study of the interplay between angiogenesis and lymphangiogenesis; d) Design and validation of imaging modalities to visualize normal and tumor lymphatics.

See full description in the NIH Guide: PAR-07-420

See description of NCI areas of research interest: NOT-CA-07-022