The EBRG can support: 1) innovative, high-risk, high pay-off projects; 2) exploration of new approaches or concepts to a particular substantive area; 3) research and development of new technologies, techniques or methods; or 4) initial research and development of data upon which significant future research may be built. In keeping with the intent of the R21 program, there may or may not be any preliminary results.

See full description in NIH Guide: PA-06-418