UC Davis Mouse Cancer Imaging Program
Simon R. Cherry, Principal Investigator
University of California, Davis
Grant number: U24CA110804
The UC Davis Mouse Cancer Imaging Program (MCIP) integrates our expertise and resources in small animal imaging and mouse pathology, with our leading cancer researchers, to create new opportunities and directions for studying the basic biology, treatment and prevention of cancer. The MCIP is part of the new Center for Molecular and Genomic Imaging (CMGI), a 4000 sq. ft. dedicated core facility for small-animal imaging located in the Genome and Biomedical Sciences Facility at UC Davis. The CMGI currently has 3 microPET scanners (microPET II, microPET Focus 120, microPET P4), bioluminescence imaging (Xenogen IVIS 100), ultrasound (Siemens Antares with research interface), and 2-D digital fluorescence and autoradiography imaging (Amersham Biosciences Storm 860). As part of the SAIRP, we will be adding microCT capability and adding an upgrade to the Xenogen system to make it capable of in vivo fluorescence imaging. Mouse pathology also forms an integral part of the MCIP and is incorporated through expertise in the UC Davis Mouse Biology Program. The MCIP is enhanced by a range of important ancillary resources, including a biomedical cyclotron (CTI RDS 111) and radiochemistry program, expertise in mouse handling and physiologic monitoring, core laboratories and expertise for creating genetically-engineered mouse models, and support for networking, data handling, databases, and biostatistics.
The MCIP currently supports a range of base grants covering basic cancer biology, mouse models of human cancer, and development and validation of diagnostic and therapeutic agents for novel cancer targets. The MCIP also supports imaging for one of the Mouse Models of Human Cancer Consortium (MMHCC) grants (PI Cory Abate-Shen, UMDNJ). Research projects supported by the MCIP include the development of a fast dynamic CT system for small animal imaging and a low-cost PET scanner for the biology lab. Other components of the MCIP include the development of an extensive database and archiving system for data and image management, and a yearly workshop on small-animal imaging techniques and methods.
The overall goal of the MCIP is to provide cancer researchers at UC Davis and collaborating institutions with the knowledge, support and technology to carry out in vivo imaging studies in mouse models of cancer, and to further develop the technologies and methods for small-animal imaging, including radiotracer and contrast agent development, instrumentation, and quantitative data analysis.