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Breast Cancer Multi-Dimensional Diffuse Optical Imaging
Bruce Tromberg, Ph.D., Principle Investigator
tromberg@laser.bli.uci.edu
University of California, Irvine
Grant Number: 1U54CA105480-01
Participating Organizations
- Academic: University of California, Irvine, NIH Intramural Research, University of Pennsylvania, University of Illinois, Urbana-Champaign, Massachusetts General Hospital, Dartmouth Medical
- Industrial: Siemens Corp, Newport Corp, ISS Inc, ART Inc, General Electric
- Planned Associate Members: American College of Radiology Imaging Network, University of California, San Francisco, Food and Drug Administration, European Breast Cancer Consortium, Applied Photonics, SPIE - International Society for Optical Engineering
Modalities
Optical diffusion mammography, combined MRI-optical tomography systems, digital mammography, localized spectroscopy, broadband molecular imaging of multiple optical probe agents, data processing and computer aided diagnosis.
Clinical Impact
This team is set to validate and translate optical and multimodality approaches to breast cancer diagnosis, treatment, and treatment monitoring. They will leverage current-art imaging hardware at sites that include an NCRR P41Research Resource Center, 5 NCI Comprehensive Cancer Centers, Program Projects for breast cancer screening and diagnosis to be combined on a standardized platform supported by industry, with clinical evaluation at the five Comprehensive Cancer Centers. Methods include broadband molecular imaging of several optical probes, combined modalities (MRI/Optical) and data processing to improve specificity for breast cancer diagnosis and monitoring the response to hormone replacement and neo-adjuvant chemotherapy.
Strengths
Substantial participation by major cancer centers and business participants assure broadly based clinical validations and rapid dispersal to clinical application through marketed products. They present a thorough, comprehensive approach to melding several optical approaches with more established breast cancer imaging modalities with excellent prospects of improving sensitivity and greater gains in specificity and reduced false positives and false negatives.
Synergisms with Other Teams
They will provide a common platform for breast optical tomography. Several other teams have complementary projects for nodal assessments that could help this team, and this team would provide focused targets for their technologies.
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