Requests for resources may be made on the first of every month, after consultation with program staff. Scientists are invited to submit innovative and compelling discoveries that have no existing avenue for pre-clinical development aimed toward application for an IND. Requests for resources will be competitively reviewed as described above (i.e., by a evaluation panel composed of outside experts). The number of projects to be supported at any given time will depend on both the level of merit and the availability of funds. Approved projects will receive the type of assistance requested to ensure the filing of an IND application at the earliest feasible date.
The decision to develop a new diagnostic agent for clinical use is not an unconditional commitment. Development will proceed sequentially, in logical order, through the routing suggested by the NCI staff. The start of one segment of the process (e.g., toxicology or dosimetry) will depend on satisfactory completion of the preceding segments (e.g., formulation). Insurmountable difficulties in any one segment may force abandonment of individual projects, as is true in any development program.
The DCIDE Process
Pre-Clinical Development & Testing