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Stage I: Scientific Merit (non-NCI reviewers):
- Strength of scientific evidence and hypothesis
- Certification (biochemical or physiological validation)
- Potential clinical impact
- Feasibility
- Novelty
Stage II: Operational Feasibility (NCI staff):
- Resource availability
- Potential impact on current or proposed clinical trials by NCI
- Magnitude of required pre-clinical studies to address scientific/regulatory issues
- Resource intensity, i.e., costs and benefits
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