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Newsletter No. 90 -- November 2006

Newsletter No. 90 -- December 2006

NIH - New Funding Initiatives

Research Project Grant (Parent R01) (PA-07-070)
This is the notice for the generic R01 for use in the electronic application.

Nanoscience and Nanotechnology in Biology and Medicine (R01:PAR-07-270); (R21: PAR-07-271)
Application Submission/Receipt Date(s): February 20, June 20, October 22, 2007
This funding opportunity (FOA) is aimed at enhancing nanoscience and nanotechnology research focused on problems in biology and medicine. Nanoscience and nanotechnology refer to research and development on the understanding and control of matter at a length scale of approximately 1 - 100 nanometers, where novel properties and functions occur because of the size. The National Cancer Institute (NCI) is interested in: 1. Early detection of the disease using imaging, 2. In vitro early diagnostics: multiplexed sensitive and specific sensors, 3. Multi-functional therapeutics and localized therapy delivery, and 4. Tools and approaches to interrogate, understand, and manipulate single cells, structures , and molecules.

URL: (R01) (R21)

Shared Instrumentation Grant Program (S10) (NCRR)(PAR-07-105)
Application Receipt/Submission Date(s): March 21, 2007
The NCRR Shared Instrument Grant (SIG) program solicits applications from groups of NIH-supported investigators to purchase or upgrade commercially available instruments that cost at least $100,000. The maximum award is $500,000. Types of instruments supported include confocal and electron microscopes, biomedical imagers, mass spectrometers, DNA sequencers, biosensors, cell sorters, X-ray diffraction systems, and NMR spectrometers among others.

Pathogenesis And Treatment Of Lymphedema And Lymphatic Diseases (R01) (PA-07-165)
Application Receipt/Submission Date(s): Multiple dates, see announcement.
The purpose of this Funding Opportunity Announcement (FOA) is to stimulate research on the lymphatic system, to characterize its function on the molecular, cellular, tissue, organ, and intact organism levels and pathophysiologic mechanisms that cause disease, to develop new methods for imaging and/or quantitating lymph flow, and to discover new therapeutic interventions, including nursing, complementary and alternative treatments.

Etiology, Prevention, and Treatment of Hepatocellular Carcinoma (R01) (NIDDK, NIBIB, NIAAA) (PA-07-258)
Research activities are encouraged in the broad areas of etiology and etiologic mechanism(s) of liver cancer, including: Identification of viral and host factors; development of animal models and in vitro viral cultivation methods; development of prevention and control strategies, including chemoprevention, validation of markers, and clinical trials of promising agents; and conduct of treatment and diagnosis research, including imaging studies.

Ancillary Studies to the AD Neuroimaging Initiative (R01) (NIA, NIBIB) (PA-07-134)
Application Receipt/Submission Date(s): Standard dates apply, closing Nov 7, 2007
This FOA invites research grant applications for ancillary studies to the Alzheimer's Disease Neuroimaging Initiative (ADNI), a multi-site, longitudinal, prospective, naturalistic study of normal cognitive aging, mild cognitive impairment (MCI), and early Alzheimer's disease (AD). The ADNI is collecting, processing, and storing serial blood, CSF, and urine samples in the three groups for analyses for potential biomarkers of disease progression, including genomic, proteomic, and metabolomic markers that can be correlated with clinical, neuropsychological, and imaging data.

Innovations in Biomedical Computational Science and Technology Initiative (SBIR [R43/R44]) (PAR-07-160)
Innovations in Biomedical Computational Science and Technology Initiative (STTR [R41/R42]) (PAR-07-161)
Application Receipt/Submission Date(s): February 9, 2007; May 24, 2007; September 24, 2007; January 24, 2008; May 24, 2008; September 24, 2008; January 24, 2009
BISTI targets support for fundamental research in biomedical computing science and technology as well as the development and application of new biocomputing tools or technologies for a particular area(s) of scientific opportunity in biomedical research.
Programs may target one or multiple areas of biomedical computing that will enable progress in biomedical research. Examples of data types that could be considered include but are not limited to genomic sequences, biomedical images, qualitative descriptors for health and social science, remote sensing and geospatial images, and pathway data.


Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Senior Fellows (F33) (PA-07-172)
Application Receipt/Submission Date(s): Multiple dates, see announcement.
The National Institutes of Health (NIH) awards individual senior level research training fellowships to experienced scientists who wish to make major changes in the direction of their research careers or who wish to broaden their scientific background by acquiring new research capabilities as independent investigators in research fields relevant to the missions of participating NIH Institutes and Centers. The primary objective of this funding opportunity is to help ensure that diverse pools of highly trained scientists will be available in adequate numbers and in appropriate research areas to carry out the Nation's biomedical, behavioral and clinical research agendas.

Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships (F31) to Promote Diversity in Health-Related Research (PA-07-106)
Application Receipt Date(s): April 13, August 13, December 13 until 2010
The Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships to Promote Diversity in Health-Related Research will provide up to five years of support for research training leading to the Ph.D. or equivalent research degree, the combined M.D./Ph.D. degree; or another formally combined professional degree and research doctoral degree in biomedical, behavioral, health services, or clinical sciences. These fellowships will enhance the diversity of the biomedical, behavioral, health services, and clinical research labor force in the United States by providing opportunities for academic institutions to identify and recruit students from diverse population groups to seek graduate degrees in health-related research and apply for this fellowship. The overall goal of this program is to increase the number of scientists from diverse population groups who are prepared to pursue careers in biomedical, behavioral, social, clinical, or health services research.

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows (F32) (PA-07-107)
Application Receipt/Submission Date(s): Multiple dates, see announcement.
Discussion as above, for postdoctoral fellows.

Understanding the Effects of Emerging Cellular, Molecular, and Genomic Technologies on Cancer Health Care Delivery (R01) (NCI) (PA-07-260)
This Funding Opportunity Announcement (FOA) issued by the NCI solicits grant applications for health services research addressing utilization of cellular, molecular, and genetic or genomic (CMG) technologies in cancer care. Examples of CMG technologies across the cancer continuum that could be considered relevant to this FOA include, but are not limited to: Cancer Prevention, Early Detection, Diagnosis - molecular profiling and imaging of tumors to target cancer therapy to the biological characteristics of the tumor; biomarker tests for detection of recurrence; and Treatment.

Non-Invasive Methods for Diagnosis and Progression of Diabetes, Kidney, Urological, Hematological and Digestive Diseases (R01) (NIDDK) (PA-07-025)
Application Receipt/Submission Date(s): Standard dates apply
This Funding Opportunity Announcement (FOA) is a call for the application of imaging and other non- or minimally-invasive technologies to detect, characterize, diagnose, identify persons with predisposition to, or monitor treatment of diseases of interest to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH).


Establishment of Multiple Principal Investigator Awards for the Support of Team Science Projects (NOT-OD-07-017)
Beginning with research grant applications submitted for February 2007 receipt dates, the NIH will allow applicants and their institutions to identify more than one Principal Investigator (PI). The Multiple PI option will be extended to most research grant applications submitted electronically through ( using the SF424 R&R application package. Grant applications that will accommodate more than one PI beginning in February include: R01, R03, R13/U13, R15, R18/U18, R21, R21/R33, R25, R33, R34, R41, R42, R43, and R44 (see Some types of applications including individual career awards (K08, K23, etc.), individual fellowships (F31, F32, etc.), Dissertation Grants (R36), Director's Pioneer Awards (DP1), Construction Grants (C06/UC6), and Shared Instrumentation Grants (S10) will not accommodate more than a single PI. The restriction to a single PI will be described in announcements for those programs.

Extension of NIH Pilot Study to Shorten the Review Cycle for New Investigator R01 Applications
As part of the National Institutes of Health continuing commitment to new investigators, a pilot effort ( was begun in 2006 to allow new investigators to have the option of submitting a resubmission/amended R01 application for consecutive review cycles, saving four months. The two cycles of the pilot have involved over 1100 R01 applications reviewed in 40 study sections in the Center for Scientific Review. Approximately 15% of the eligible new investigators have used the option of next cycle submission. The Center for Scientific Review is committed to continuing this pilot for the current study sections and to the extension to all new investigator R01 applications by the end of 2007.

NIH Fiscal Policy for Grant Awards - FY 2007 (NOT-OD-07-030)
This Notice provides guidance to the extramural community about the NIH's Fiscal Operations Plan for FY2007.

Limits on Resubmission of an Application: Clarification of NIH Policy (NOT-OD-07-015)

New Limits on Appendix Materials for All NIH/AHRQ/NIOSH Grant Applications Beginning with Receipt Dates On or After January 3, 2007 (NOT-OD-07-018)

CIP Cancer Tracer Synthesis Resources
The Cancer Imaging Program has been creating Investigational New Drug Applications (IND) for imaging agents in order to engage in multi-center clinical trials of these materials. A subset of the documents filed is being made available to the research community to implement routine synthesis of tracers at their own facilities and to assist investigators with the filing of their own INDs. The first of these document sets is for F-18 fluorothymidine (FLT).

NIH Extramural Nexus
The NIH Extramural Nexus is a bimonthly update from the NIH Office of Extramural Research (OER), NIH. The OER is the hub for grants policy and operations, grants administration, and the coordination of NIH's extramural programs and activities. See the issues.

Interagency Council on Biomedical Imaging in Oncology Meeting
The next ICBIO meeting is Tuesday, March 27, 2007, from 8:30 AM in EPN, at 6130 Executive Boulevard, Rockville, MD. The deadline for submission is February 10, 2007.
See for details.

The Cancer Imaging Program of the NCI requests submissions for its Development of Clinical Imaging Drugs and Enhancers (DCIDE) initiative. The goal is the rapid movement of promising, novel cancer imaging enhancers or molecular probes from the laboratory to proof of principle clinical trials. See the web site for details.


Seventh National Forum on Biomedical Imaging in Oncology: Oncologic Image-Guided Interventions: Opportunities for Collaboration
February 1-2, 2007, Bethesda North Marriott, Rockville, Maryland

NIH Regional Seminars on Program Funding and Grants
In 2007, the OER will conduct seminars at the University of Utah at Salt Lake City, March 5-7, and in Research Triangle Park, NC, April 24-26, sponsored by several local higher education and research institutions. Pre-registration for the seminars is available now.

17th International Symposium on Radiopharmaceutical Sciences
April 30 - May 4, 2007, Aachen, Germany

Society of Nuclear Medicine 54th Annual Scientific Meeting
June 2 - 6, 2007, Washington, DC

Molecular Imaging Joint Conference of the Academy of Molecular Imaging and the Society for Molecular Imaging
September 7 - 11, 2007, Providence, Rhode Island

The Cancer Imaging Program at NCI has created this e-mail distribution list to notify interested people about funding opportunities and other issues related to imaging research. Its primary purpose is to call your attention to important, relevant information on NIH Web pages, or in the NIH Guide. Occasionally it may be used to clarify areas of confusion, or disseminate answers to frequently asked questions.

If you wish to remain on the list, no action is necessary. If you wish to be added to the list, please contact Dr Barbara Croft by return e-mail ( Please include your complete mailing address, title, phone and fax numbers.

Cancer Imaging Program
Division of Cancer Treatment and Diagnosis, NCI
6130 Executive Boulevard - MSC-7412
Bethesda, MD 20892-7412
Tel: 301 496 9531
Fax: 301 480 3507